If the losses are in friendly matches....
Over the last weekend and today was/is the first round of the german cup. Up to now 4 Bundesliga clubs were eliminated, all by clubs from lower leagues(2nd, 3rd and 4th). E.g. Bayer 04 Leverkusen, last year the second best team in the Bundesliga lost against Dynamo Dresden that have just been promoted to the second Bundesliga. And VfL Wolfsburg lost to 4th(regional)league team RB Leipzig.
Ciao
Hessian